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TYPE-SPECIFIC COLD AUTO-ANTIBODIES AS A CAUSE OF ACQUIRED HEMOLYTIC ANEMIA AND HEMOLYTIC TRANSFUSION REACTIONS: BIOLOGIC TEST WITH BOVINE RED CELLS

1956; American College of Physicians; Volume: 44; Issue: 2 Linguagem: Inglês

10.7326/0003-4819-44-2-221

1539-3704

Alexander S. Wiener, Lester J. Unger, Lisa J. Cohen, James A. Feldman,

Blood transfusion and management

Article1 February 1956TYPE-SPECIFIC COLD AUTO-ANTIBODIES AS A CAUSE OF ACQUIRED HEMOLYTIC ANEMIA AND HEMOLYTIC TRANSFUSION REACTIONS: BIOLOGIC TEST WITH BOVINE RED CELLSA. S. WIENER, F.A.C.P., L. J. UNGER, L. COHEN, J. FELDMANA. S. WIENER, F.A.C.P., L. J. UNGER, L. COHEN, J. FELDMANAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-2-221 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this report is to describe an unusual example of acquired hemolytic anemia in which cold auto-antibodies of extremely high titer were detected in the patient's serum. While similar cases have occasionally been reported in the past,1, 2, 3, 4, 5, 6the one to be described here exhibited certain important differences having fundamental significance. Previous experience had shown that such patients can generally be safely transfused with any blood of the homologous A-B-O group and Rh type, provided the blood is kept warm during the injection to prevent the cold auto-antibodies from reacting with the transfused cells....Bibliography1. DonathLandsteiner JK: Ueber paroxysmale Hämoglobinurie, München. med. Wchnschr. 51: 1590, 1904. Google Scholar2. McCombsMcElroy RJS: Reversible autohemagglutination with peripheral vascular symptoms, Arch. Int. Med. 59: 107, 1937. CrossrefGoogle Scholar3. Battaglia B: Hemolytic anemia complicating primary atypical pneumonia, with cold isohemagglutinins, Ann. Int. Med. 27: 469, 1947. LinkGoogle Scholar4. WienerSamwickMorrisonLoewe ASAAML: Acquired hemolytic anemia, Am. J. Clin. Path. 22: 301, 1952. CrossrefMedlineGoogle Scholar5. WienerGordonGallop ASEBC: Studies on autoantibodies in human sera, J. Immunol. 71: 58, 1953. MedlineGoogle Scholar6. Wiener AS: Blood groups and transfusion, 3d Ed., 1943, C. 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Van LoghemVan der Hart JJM: Varieties of specific autoantibodies in acquired haemolytic anaemia, Vox Sang 4: 2, 1954. Google Scholar22. Wiener AS: Rh-Hr blood types. Applications in clinical and legal medicine and anthropology, 1954, Grune and Stratton, New York, Chapter 84. CrossrefGoogle Scholar23. Wiener AS: Heredity of the M-N types. Analysis of twenty years' work, Am. J. Human Genet. 3: 179, 1951. MedlineGoogle Scholar24. Wiener AS: The solution of certain fundamental immunological problems by studies on Rh sensitization, Ann. Allergy 10: 535, 1952. MedlineGoogle Scholar25. WienerWexlerHurst ASIBJG: The use of exchange transfusion for the treatment of severe erythroblastosis due to A-B sensitization, with observations on the pathogenesis of the disease, Blood 4: 1014, 1949. CrossrefMedlineGoogle Scholar26. WienerWexler ASIB: Observations on the role of anti-C in the pathogenesis of A-B-O hemolytic disease, Rev. d'hémat. 9: 600, 1954. MedlineGoogle Scholar27. WienerUnger ASLJ: Excess of group O mothers in A-B-O hemolytic disease, with special reference to the rôle of the blood factor C , Exper. Med. and Surg. 13: 204, 1955. MedlineGoogle Scholar28. UngerWiener LJAS: Studies on the C antibody of group O serum, with special reference to its role in hemolytic disease of the newborn, J. Lab. and Clin. Med. 44: 387, 1954. MedlineGoogle Scholar29. Rosenfield RE: A-B hemolytic disease of the newborn. Analysis of 1480 cord blood specimens, with special reference to the direct antiglobulin test and to the group O mothers, Blood 10: 17, 1955. CrossrefMedlineGoogle Scholar30. WienerSamwickMorrisonCohen ASAAHL: Studies on immunization in man. I. The blood group substances A and B, Exper. Med. and Surg. 11: 267, 1953. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 21, 1955.From the Division of Immunohematology of the Jewish Hospital of Brooklyn, the Serological Laboratory of the Office of the Chief Medical Examiner of New York City, and the Blood and Plasma Bank of the New York University-Bellevue Medical Center. 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WIENER, M.D., F.A.C.P., EVE B. GORDON, ERICH RUSSOW, M.D. 1 February 1956Volume 44, Issue 2Page: 221-240KeywordsBiologicsBlood banksBlood cellsBlood plasmaCellsFibrinogenHemolytic anemiaResearch laboratories Issue Published: 1 February 1956 Copyright & PermissionsCopyright ©, 1956, by The American College of PhysiciansPDF downloadLoading ...