Human immunodeficiency virus type 1 reverse transcriptase and protease mutation search engine for queries
2000; Nature Portfolio; Volume: 6; Issue: 11 Linguagem: Inglês
10.1038/81407
ISSN1546-170X
AutoresRobert W. Shafer, Duane R. Jung, Bradley J. Betts,
Tópico(s)Biochemical and Molecular Research
ResumoGenetic research is increasingly turning to studies of sequence variation in genes encoding proteins of known structure and function. The principal question in these studies is whether sequence variation affects protein structure or function, and, for certain genes, whether sequence variation affects human health. The proliferation of published sequence data and the growth in the number of publications is a boon to this research, but also makes it difficult to keep track of what is known about a gene. The primary sequence databases of the International Nucleic Acid Sequence Data Library (for example, GenBank) provide powerful sequence-similarity search tools that help researchers deduce the functions of newly identified proteins 1‐3
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