Alkalosis resulting from combined administration of a “nonsystemic” antacid and a cation-exchange resin
1969; Elsevier BV; Volume: 56; Issue: 5 Linguagem: Inglês
10.1016/s0016-5085(69)80090-9
ISSN1528-0012
Autores Tópico(s)Gastroesophageal reflux and treatments
ResumoSummary The effect upon acid base balance of combined oral administration of cation exchange resins and nonabsorbable antacids was studied. The combination of a sodium polystyrene sulfonate resin with a magnesium hydroxide-containing antacid consistently produced systemic alkalinization. Substitution of calcium phase resin for sodium phase resin resulted in loss of the alkalinizing effect of the regimen. The alkalinization resulted from systemic base accumulation; this effect is probably dependent upon cation exchange properties of the resin altering the usual chemical reactions of magnesium hydroxide in the duodenum and upper jejunum. Systemic alkalinization was also demonstrated when the resin was given with calcium carbonate. It is suggested that reactions similar to those with magnesium hydroxide are involved. These findings support a proposed mechanism explaining the nonsystemic nature of certain antacids. They also help to explain certain relations between calcium carbonate ingestion and systemic alkalosis.
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