CLINICAL AND LABORATORY OBSERVATIONS ON AUTOIMMUNE HEMOLYTIC DISEASE
1951; American College of Physicians; Volume: 35; Issue: 3 Linguagem: Inglês
10.7326/0003-4819-35-3-507
ISSN1539-3704
AutoresL. E. Young, George Miller, Richard M. Christian,
Tópico(s)Neonatal Health and Biochemistry
ResumoArticle1 September 1951CLINICAL AND LABORATORY OBSERVATIONS ON AUTOIMMUNE HEMOLYTIC DISEASELAWRENCE E. YOUNG, F.A.C.P., GERALD MILLER, M.D., RICHARD M. CHRISTIAN, M.D.LAWRENCE E. YOUNG, F.A.C.P., GERALD MILLER, M.D., RICHARD M. CHRISTIAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-3-507 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe term "acquired hemolytic anemia" has in the past been rather loosely applied to a heterogeneous group of hemolytic processes, but there has been a growing tendency to consider separately cases in which the patients have developed antibodies reacting with their own red corpuscles. Since our understanding of the autoimmune group of hemolytic disorders has grown rapidly during the past five years, it is appropriate that some of the recently accumulated information be analyzed at this time from the viewpoint of the internist.This can best be done by considering autoimmune hemolytic disease with respect to: (1) serologic findings and...Bibliography1. EvansDuane RSR: Hemolytic anemia; recent advances in diagnosis and treatment, California Med. 70: 244-251, 1949. MedlineGoogle Scholar2. DameshekRosenthalSchwartz WMCLI: The treatment of acquired hemolytic anemia with adrenocorticotropic hormone (ACTH), New England J. Med. 244: 117-127, 1951. CrossrefGoogle Scholar3. YoungChristianIzzo LERMMJ: Some newer concepts of congenital and acquired hemolytic anemias, M. Clin. North America 35: 571-585, 1951. CrossrefMedlineGoogle Scholar4. CoombsMourantRace RRAERR: Detection of weak and "incomplete" Rh agglutinins: a new test, Lancet 2: 15, 1945. 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Author, Article, and Disclosure InformationAffiliations: *Presented at the Thirty-second Annual Session of the American College of Physicians, St. Louis, Mo., April 11, 1951.From the Department of Medicine, The University of Rochester School of Medicine and Dentistry, and the Medical Clinics of the Strong Memorial and Rochester Municipal Hospitals.The observations summarized in this paper were aided by a contract between the Office of Naval Research, Department of the Navy, and the University of Rochester (NR131-174), and were supported in part by the Hochstetter Fund.†We have encountered cases of chronic hemolytic disease in which no autoantibodies could be demonstrated but in which the hematologic findings and clinical course appeared to be the same as in the cases described in this paper. The nature of the hemolytic agent or agents in such cases is obscure. It seems possible that autoantibodies may ultimately be demonstrated in the blood of some of these individuals if more sensitive serologic technics can be developed. It is also quite possible that non-immune mechanisms are responsible for the hemolytic process in certain instances. 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