The effect of dimethyl sulfoxide (DMSO) on permeability of Staphylococcusaureus
1968; Elsevier BV; Volume: 32; Issue: 6 Linguagem: Inglês
10.1016/0006-291x(68)90118-6
ISSN1090-2104
AutoresBahram M. Ghajar, Shirley A. Harmon,
Tópico(s)Phytochemicals and Antioxidant Activities
ResumoIn recent years a great deal of attention has been devoted to finding biological and therapeutic uses of dimethyl sulfoxide. Many studies have been made on the reduction of permeability barriers of plant and animal cells when this compound was used in conjunction with chemicals and drugs (see Vol. 141 (1967), Ann. N. Y.Acad. Sci.). Only limited studies concerning the effect of DMSO on microorganisms have been made, and very little is known about the mode of action of DMSO. This report concerns some studies made on the effect of DMSO on permeability of Staphylococcusaureus. Treating staphylococci with DMSO was found to result in a greater rate of oxygen and lactose uptake, while the rate of glycine transport was reduced. Some possible mechanisms for the mode of action of this compound are also discussed.
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