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Vitamin C Restores Behavioral Deficits and Amyloid-β Oligomerization without Affecting Plaque Formation in a Mouse Model of Alzheimer's Disease

2011; IOS Press; Volume: 26; Issue: 1 Linguagem: Inglês

10.3233/jad-2011-101971

1875-8908

Kazuma Murakami, Nakaba Murata, Yusuke Ozawa, Noriaki Kinoshita, Kazuhiro Irie, Takuji Shirasawa, Takahiko Shimizu,

Vitamin C and Antioxidants Research

Oxidative stress is related to the pathogenesis of Alzheimer's disease (AD) characterized by progressive memory impairment. Soluble amyloid-β (Aβ) oligomers cause cognitive loss and synaptic dysfunction rather than senile plaques in AD. The decline o