Regulatory Roles for Cytokine- Producing B Cells in Infection and Autoimmune Disease
2004; Linguagem: Inglês
10.1159/000082086
AutoresFrances E. Lund, Beth A. Garvy, Troy D. Randall, David P. Harris,
Tópico(s)Immune Cell Function and Interaction
ResumoRecent experiments have revealed that B cells can regulate the course of immune responses to pathogens and autoantigens by antibody-independent mechanisms. One antibodyindependent function of B cells is to produce cytokines. In this review we describe the identification of IL-10-producing ʼregulatoryʼ B cells as well as IFNγ-producing ʼeffectorʼBe1 cells and IL-4-producing ʼeffectorʼ Be2 cells. We discuss the roles of antigen, pathogen-derived molecules and T cell and dendritic cell-derived factors in regulating the differentiation of mature B cells into cytokine-producing effector B cells. We also review the recent experiments showing that B cell-derived cytokines play pathologic as well as protective roles in immune responses to autoantigens, and demonstrate that cytokine-producing B cells play unexpectedly complex and potentially opposing roles in autoimmune disease.
Referência(s)