The Crystal Structure and Absolute Configuration of the Antitumor Platinum Complex tran(OH)-Pt(OH)<SUB>2</SUB>(Malonato)(1R, 2R, -Cyclohexanediamine)
1992; Pharmaceutical Society of Japan; Volume: 40; Issue: 4 Linguagem: Inglês
10.1248/cpb.40.1022
ISSN1347-5223
AutoresMasafumi Goto, Junzo Hirose, Masahide Noji, Keun-Im LEE, Reiko Saito, Yoshinori Kidani,
Tópico(s)Ferrocene Chemistry and Applications
ResumoThe absolute configuration of the anti-tumor complex trans(OH)-Pt(OH)2(malonato)(1R,2R-cyclohexanediamine) was determined by X-ray anomalous scattering technique. The final unit cell was monoclinic, space group P2(1) with a = 9.142 A, b = 7.788 A, c = 11.946 A, beta = 96.48 degrees, Z = 2. The crystal structure was determined by direct method and difference Fourier synthesis, and refined to R = 0.025 and Rw = 0.033 based on 2768 independent reflections. The platinum atom has roughly octahedral coordination. The cyclohexane ring has the expected chair configuration, with two amino groups in equatorial positions while the malonato ligand, in contrast, shows a boat conformation for six membered Pt O-C-C-C-O ring.
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