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Standardizing Chemical Peel Solution Formulations to Avoid Mishaps

1994; Wiley; Volume: 20; Issue: 12 Linguagem: Inglês

10.1111/j.1524-4725.1994.tb03710.x

2374-846X

James B. Bridenstine, J Doležal,

Bee Products Chemical Analysis

background . Chemical peeling using trichloroacetic acid (TCA) is a populär and long utilized procedure in dermatology and cosmetic surgery. objective . To determine the actual concentration of TCA infour disparate methods of preparation of Solutions, expressed in the Standard pharmaceutical method of weight to volume (wt/vol). methods . Method I was wt/vol, method H was weight to weight (wt/wt), method III was grams of TCA added to 100 cc water, and method IV was the usage of saturated TCA, and calling it 100%, then making appropriate dilutions. The amounts of TCA in each Solution for methods II, III, and IV were converted, by calculation, to the wt/vol method. results . The relative concentrations of TCA, ranked by the wt/vol pharmaceutical Standard, showed that from strongest to weakest: method IV > method II > method I > method III. conclusions . Tremendous variations were found in the relative concentrations of TCA in these Solutions. To avoid mishaps and complications, the wt/vol method should be used.