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A METHOD FOR THE CONTINUOUS RECORDING OF GASTRIC pH IN SITU. IV. FURTHER EVALUATION OF THE EFFICACY OF ANTACIDS IN VITRO AND IN THE HUMAN BEING

1943; American College of Physicians; Volume: 18; Issue: 2 Linguagem: Inglês

10.7326/0003-4819-18-2-193

1539-3704

N.E. Rossett, James Thomas Flexner,

Gastroesophageal reflux and treatments

Article1 February 1943A METHOD FOR THE CONTINUOUS RECORDING OF GASTRIC pH IN SITU. IV. FURTHER EVALUATION OF THE EFFICACY OF ANTACIDS IN VITRO AND IN THE HUMAN BEINGN. E. ROSSETT, M.D., JAMES FLEXNER, M. D.N. E. ROSSETT, M.D.Search for more papers by this author, JAMES FLEXNER, M. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-2-193 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA method for the continuous recording of gastric pH in situ was recently described1, 2 and utilized in providing continuous pH recordings in vivo (dogs) and in vitro. Sodium bicarbonate, Sippy A powders, magnesium trisilicate, magnesium superoxol, and aluminum hydroxide were tested.3 The present communication deals with titrations in vitro and in the human stomach of these and other antacids commonly used in ulcer therapy.MATERIALS AND METHODSIn Vitro. Thirty c.c. of 0.1 normal hydrochloric acid and 70 c.c. of distilled water were placed in a beaker to represent the fasting contents (pH 1.4) of a hyperchlorhydric human stomach....References1. FLEXNERKNIAZUKNYBOER JMJ: Method for continuous recording of gastric pH in situ, Science, 1939, xc, 239. CrossrefGoogle Scholar2. FLEXNERKNIAZUK JM: A method for the continuous recording of gastric pH in situ. II. Experimental details, Am. Jr. Digest. Dis., 1940, vii, 138. CrossrefGoogle Scholar3. FLEXNERKNIAZUK JM: A method for the continuous recording of gastric pH in situ. III. Evaluation of the efficacy of certain antacids, Am. Jr. Digest. Dis., 1941, viii, 45. CrossrefGoogle Scholar4. VAN LIERESLEETH EJCK: The emptying time of the normal human stomach as influenced by acid and alkali, Am. Jr. Digest. Dis., 1940, vii, 118. CrossrefGoogle Scholar5. BLOOMFIELDCHENFRENCH ALCKLR: Basal gastric secretion as a clinical test of gastric function with special reference to peptic ulcer, Jr. Clin. Invest., 1940, xix, 863. CrossrefGoogle Scholar6. GARLIN C: Sécrétion gastrique provoquée par simple présence d'une sonde d'Einhorn dans les voies digestives, Bull. et mém. Soc. med. d. hôp. de Paris, 1929, liii, 984. Google Scholar7. HARDYQUANSTRON HHVE: Effect of gastric distension on gastric secretion, Proc. Soc. Exper. Biol. and Med., 1937, xxxvii, 28. CrossrefGoogle Scholar8. BRIDGESMATTICE MAMR: Over 2000 estimations of the pH of representative foods, Am. Jr. Digest. Dis., 1939, vii, 440. CrossrefGoogle Scholar9. MUTCH N: Synthetic magnesium trisilicate. Its action in the alimentary tract, Brit. Med. Jr., 1936, i, 205. CrossrefGoogle Scholar10. KOMEROVKOMEROV SAO: The precipitability of pepsin by colloidal aluminum hydroxide, Am. Jr. Digest. Dis., 1940, vii, 66. Google Scholar11. SCHIFFRINKOMEROV MJSA: The inactivation of pepsin by compounds of aluminum and magnesium, Am. Jr. Digest. Dis., 1941, viii, 215. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 6, 1941.From the Second (Cornell) Medical Division, Bellevue Hospital, and the Department of Medicine, Cornell Medical College. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAN IN VITRO EVALUATION OF COMMONLY USED ANTACIDS WITH SPECIAL REFERENCE TO ALUMINIUM HYDROXIDE GEL AND DRIED ALUMINIUM HYDROXIDE GELThe Routine Determination of the Antacid Efficiency of Aluminium Hydroxide GelsTHE IN VITRO EVALUATION OF A SODIUM POLY-HYDROXYALUMINIUM MONOCARBONATE HEXITOL COMPLEX AS A GASTRIC ANTACIDContinuous records of gastric ρh in situ and their possible use in pre-operative assessment of peptic ulcer patientsRecent advances in pediatric nuclear medicineDrug Information Analysis ServiceEvaluation of Antacids in Man Using the Heidelberg CapsuleLocalised Determination of the Intragastric pH Value during GastroscopyAutomated Technique for Determining Dissolution and Reaction Rates of Antacids IIAutomated Technique for Determining Dissolution and Reaction Rate of Antacids IProblems Associated with Assessment of the Effects of Diet, Antacids, and Anticholinergic Agents on Gastric and Duodenal Acidity, as Measured by the Glass Electrode in situIntragastric pH Recording in Controlled Series of Double TestsPreparation and Properties of New Gastric Antacids I**Received September 2, 1959, from the Research Laboratory, Reheis Co., Inc., Berkeley Heights, N. 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Comparative biochemical and economic considerationsExamination of Gastric Activity by Means of Dialysis in the StomachComparative In Vivo Methods for Evaluating Antacids in Humans**La Wall and Harrisson Research Laboratories, 1921 Walnut Street, Philadelphia 3, Pa.An Approach to Antacid Evaluation**St. Louis College of Pharmacy and Allied Sciences, St. Louis, Mo.A Comparative in Vho Study of Antacids I**LaWall and Harrisson Research Laboratories, Philadelphia 3, Pa.Continuously Recorded in Situ pH of Gastric and Duodenal Contents in Patients with and Without Duodenal UlcersEvaluation of Antacid Liquid Suspensions and Tablets in Relation to Secretory DynamicsStudies on antacids. V. The preparation and properties of dihydroxy aluminum sodium carbonateA Study of AntacidsAn In Vitro Evaluation of the Efficacy of the More Frequently Used Antacids with Particular Attention to TabletsIn Vitro Differences Between Dihydroxy Aluminum Aminoacetate and Dried Aluminum Hydroxide GelPEPTIC ULCER: MEDICAL CURE BY EFFICIENT GASTRIC ACID NEUTRALIZATION*N. E. ROSSETT, M.D., F.A.C.P., F. H. KNOX JR., M.D., S. L. STEPHENSON JR., M.D.Peptic Ulcer in Man Part 5. A new Antacid, SCMC, made to meet requirements of Antacid Therapy. Clinical EvaluationMedical Applications of Adsorption and Ion Exchange MaterialsAntacid Efficacy in Vitro of Some Foods Commonly Used in Peptic Ulcer DietsPeptic ulcer at fort sill 1 February 1943Volume 18, Issue 2Page: 193-200KeywordsBicarbonatesGastric ulcersHospital medicineHydrochloric acidMagnesiumSodiumStomach ePublished: 1 December 2008 Issue Published: 1 February 1943 PDF downloadLoading ...