The catalytic mechanism of transketolase. Thiamin pyrophosphate-derived transition states for transketolase and pyruvate dehydrogenase are not identical.
1983; Elsevier BV; Volume: 258; Issue: 20 Linguagem: Inglês
10.1016/s0021-9258(17)44189-5
ISSN1083-351X
AutoresDavid S. Shreve, M P Holloway, Jesse C. Haggerty, Henry Z. Sable,
Tópico(s)Amino Acid Enzymes and Metabolism
ResumoThiamin thiazolone pyrophosphate (TTPP) has been reported to be an effective transition state analogue for the thiamin pyrophosphate-dependent partial reaction of pyruvate dehydrogenase (Gutowski, J. A.,
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