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Potential Warfarin‐Ciprofloxacin Interaction in Patients Receiving Long‐Term Anticoagulation

1992; Wiley; Volume: 12; Issue: 6 Linguagem: Inglês

10.1002/j.1875-9114.1992.tb04485.x

1875-9114

Theresa Bianco, Henry I. Bussey, Lisa Farnett, William D. Linn, Maura K. Roush, Y.W. James Wong,

Sepsis Diagnosis and Treatment

This study prospectively evaluated the potential interaction between the oral anticoagulant warfarin and the quinolone antimicrobial agent ciprofloxacin. After a 10-day placebo lead-in phase, 16 patients stabilized with long-term warfarin therapy were randomized to receive ciprofloxacin 500 mg or a matching placebo twice/day for 10 days. International normalized ratios (INRs) measured by both standard laboratory analysis and by Coumatrak (finger-stick) methods were evaluated at 3- to 5-day intervals. No patient experienced a significant increase in INR. No patient experienced a bleeding event. These data support the fact that a warfarin-ciprofloxacin interaction does not routinely occur at this dosage and duration of ciprofloxacin therapy.