Antigen mimicry involving measles virus hemagglutinin and human respiratory syncytial virus nucleoprotein
1986; American Society for Microbiology; Volume: 57; Issue: 1 Linguagem: Inglês
10.1128/jvi.57.1.394-396.1986
ISSN1098-5514
AutoresErling Norrby, Hooshmand Sheshberadaran, B Rafner,
Tópico(s)Virus-based gene therapy research
ResumoIntergenic antigenic relationships between measles virus and respiratory syncytial (RS) virus-specific structural components were studied by using monoclonal antibodies. Of 75 monoclonal antibodies against these components, only one, an anti-measles virus hemagglutinin monoclonal antibody, cross-reacted. Immunofluorescence analysis of measles virus- and RS virus-infected cells with this monoclonal antibody showed qualitatively different staining patterns which indicated that the antigen involved in cross-reaction was the RS virus nucleoprotein or phosphoprotein. A radioimmunoprecipitation assay showed the antigen to be the nucleoprotein.
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