Produção Nacional
Revisado por pares
Maternal Alcohol Consumption during Pregnancy and Early Age Leukemia Risk in Brazil
2015; Hindawi Publishing Corporation; Volume: 2015; Linguagem: Inglês
10.1155/2015/732495
ISSN2314-6141
AutoresJeniffer Dantas Ferreira, Arnaldo Cézar Couto, Mariana Emerenciano, Maria S. Pombo‐de‐Oliveira, Sérgio Koifman,
Tópico(s)Childhood Cancer Survivors' Quality of Life
ResumoObjectives . To investigate the association between the maternal alcohol consumption during pregnancy and early age leukemia (EAL) in offspring. Methods . Datasets were analyzed from a case-control study carried out in Brazil during 1999–2007. Data were obtained by maternal interviews using a standardized questionnaire. The present study included 675 children (193 acute lymphoid leukemia (ALL), 59 acute myeloid leukemia (AML), and 423 controls). Unconditional logistic regression was performed, and adjusted odds ratios (adj. OR) on the association between alcohol consumption and EAL were ascertained. Results . Alcohol consumption was reported by 43% of ALL and 39% of AML case mothers and 35.5% of controls’. Beer consumption before and during pregnancy was associated with ALL in crude analysis (OR = 1.54, 95% CI, 1.08–2.19), although in adjusted analysis no statistical significance was found. For weekly intake of ≤1 glass (adj. OR = 1.30, 95% CI, 0.71–2.36) and ≥1 glass/week (adj. OR = 1.47, 95% CI, 0.88–2.46) a potential dose-response was observed ( P trend < 0.03). Conclusion . This study failed to support the hypothesis of an increased risk of EAL associated with maternal alcohol intake during pregnancy, neither with the interaction with tobacco nor with alcohol consumption.
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