Anemia and Edema of Chronic Choline Deficiency in the Rat
1948; Elsevier BV; Volume: 36; Issue: 6 Linguagem: Inglês
10.1093/jn/36.6.739
ISSN1541-6100
Autores Tópico(s)Folate and B Vitamins Research
ResumoProlonged feeding of diets deficient in choline produced an anemia in rats. The hemoglobin levels in the deficient animals ranged from 6.25 to 11.95 gm per 100 ml of blood. The anemia was prevented by dietary supplements of choline chloride or DL-methionine. The sodium salt pteroyl-diglutamic acid was ineffective as a curative agent. The prolonged feeding of diets low in protein and choline resulted in symptoms of severe nutritional edema in 7 of 12 rats. This condition was not observed in control animals receiving the same diets supplemented with choline.
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