Portal de Periódicos da CAPES

Nuclear Receptor LXR: A New Partner for Sodium-Dependent Phosphate Cotransporters

2013; Karger Publishers; Linguagem: Inglês

10.1159/000346782

1662-2782

Yupanqui Caldas, Héctor Giral, Vı́ctor Sorribas, Moshe Levi,

Parathyroid Disorders and Treatments

New pharmaceutical research approaches are focusing on trying to alleviate the perturbed phosphate (Pi) homeostasis associated with the onset of chronic kidney disease; this includes activation of some of the nuclear receptors. We have recently reported the down regulation of the intestinal and renal sodium-phosphate (NaPi) cotransporters by the liver X receptor (LXR) agonists, and the consequent decrease of the serum Pi levels. In this review, we describe our current knowledge of the different proteins involved in the renal and intestinal actions of LXR.