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ESC Guidelines on Management of Acute Myocardial Infarction in Patients Presenting With Persistent ST-Segment Elevation

2009; Elsevier BV; Volume: 62; Issue: 3 Linguagem: Inglês

10.1016/s1885-5857(09)71559-2

1885-5857

Frans Van de Werf, Jeroen J. Bax, Amadeo Betriu, Carina Blomström‐Lundqvist, Filippo Crea, Volkmar Falk, Gerasimos Filippatos, Keith A.A. Fox, Kurt Huber, Adnan Kastrati, Annika Rosengren, Philippe Gabríel Steg, Marco Tubaro, Freek W.A. Verheugt, Franz Weidinger, Michael Weis,

Cardiac Structural Anomalies and Repair

Uterus transplantation has proven to be a successful treatment for women with absolute uterine infertility, caused either by the absence of a uterus or the presence of a nonfunctioning uterus. We report the first birth of a healthy child following uterus transplantation in the United States, from a recipient of a uterus allograft procured from an altruistic living donor. Two major modifications from the previously reported live births characterized this uterus transplant. First, the transplanted uterus relied upon and sustained the pregnancy while having only the utero-ovarian vein as venous outflow. The implication is a significantly simplified living donor surgery that paves the way for minimally invasive laparoscopic or robot-assisted techniques for the donor hysterectomy. Second, the time from transplantation to embryo transfer was significantly shortened from prior protocols, allowing for an overall shorter exposure to immunosuppression by the recipient and lowering the risk for potential adverse effects from these medications.