Biosynthesis of , a putative C5 intermediate in the mevalonate independent pathway for isoprenoid biosynthesis
1997; Elsevier BV; Volume: 38; Issue: 27 Linguagem: Inglês
10.1016/s0040-4039(97)01045-9
ISSN1873-3581
AutoresTore Duvold, Jean-Michel Bravo, Catherine Pale-Grosdemange, Michel Rohmer,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoAccording to incorporations of 13 labelled glucose, 2-C-methyl-d-erythritol was most likely synthesized by Corynebacterium ammoniagenes from glyceraldehyde 3-phosphate and from pyruvate via a condensation and a rearrangement. The observed labelling patterns for methylerythritol were identical with those of the isoprenic units of dihydromenaquinones from the same bacterium, suggesting for this tetrol an intermediate role in the non-mevalonate pathway for isoprenoid biosynthesis.
Referência(s)