Portal de Periódicos da CAPES

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

1995; Springer Nature; Volume: 14; Issue: 15 Linguagem: Inglês

10.1002/j.1460-2075.1995.tb00029.x

1460-2075

Paul Säftig, Michal Hetman, Wolfgang W. Schmahl, Karin Weber, Lutz Heine, Horst Mossmann, Anja Köster, Barbara Heß, Meike Evers, Kurt Von Figura,

Cell death mechanisms and regulation

Research Article1 August 1995free access Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. P. Saftig P. Saftig Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author M. Hetman M. Hetman Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author W. Schmahl W. Schmahl Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author K. Weber K. Weber Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author L. Heine L. Heine Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author H. Mossmann H. Mossmann Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author A. Köster A. Köster Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author B. Hess B. Hess Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author M. Evers M. Evers Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author K. von Figura K. von Figura Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author P. Saftig P. Saftig Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author M. Hetman M. Hetman Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author W. Schmahl W. Schmahl Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author K. Weber K. Weber Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author L. Heine L. Heine Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author H. Mossmann H. Mossmann Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author A. Köster A. Köster Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author B. Hess B. Hess Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author M. Evers M. Evers Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author K. von Figura K. von Figura Abt. Biochemie II, Universität Göttingen, Germany. Search for more papers by this author Author Information P. Saftig1, M. Hetman1, W. Schmahl1, K. Weber1, L. Heine1, H. Mossmann1, A. Köster1, B. Hess1, M. Evers1 and K. Figura1 1Abt. Biochemie II, Universität Göttingen, Germany. The EMBO Journal (1995)14:3599-3608https://doi.org/10.1002/j.1460-2075.1995.tb00029.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Mice deficient for the major lysosomal aspartic proteinase cathepsin D, generated by gene targeting, develop normally during the first 2 weeks, stop thriving in the third week and die in a state of anorexia at day 26 +/− 1. An atrophy of the ileal mucosa first observed in the third week progresses towards widespread intestinal necroses accompanied by thromboemboli. Thymus and spleen undergo massive destruction with fulminant loss of T and B cells. Lysosomal bulk proteolysis is maintained. These results suggest, that vital functions of cathepsin D are exerted by limited proteolysis of proteins regulating cell growth and/or tissue homeostasis, while its contribution to bulk proteolysis in lysosomes appears to be non-critical. Previous ArticleNext Article Volume 14Issue 151 August 1995In this issue RelatedDetailsLoading ...