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Suppressor Cells for the Afferent Phase of Contact Sensitivity to Picryl Chloride: Inhibition of DNA Synthesis Induced by T Cells from Mice Injected with Picryl Sulfonic Acid

1979; American Association of Immunologists; Volume: 122; Issue: 6 Linguagem: Inglês

10.4049/jimmunol.122.6.2300

1550-6606

Wayne Thomas, M C Watkins, G L Asherson,

Immune Response and Inflammation

Abstract Previous reports have shown that picryl sulfonic acid (PSA) induces suppressor T cells that inhibit the effector phase of contact sensitivity, whereas its DNP counterpart, dinitrobenzenesulfonate (DNBS) induces cells that inhibit the afferent phase of sensitization. Accordingly, cells from mice injected with DNBS, but not PSA, could be shown to inhibit the DNA synthesis in the lymph nodes that occurs during sensitization. It is now shown that PSA does induce T cells that suppress DNA synthesis but this can only be detected with enriched T cells or by using a regimen of PSA injection different from previously used to induce suppressor cells for the effector phase. The T cells did not affect responses to oxazolone or dinitrofluorobenzene (DNFB) and were distinguishable from suppressors of the efferent phase in that they could be produced in adult thymectomized but not cyclophosphamide-treated mice. T cells from mice injected with DNBS that inhibited DNA synthesis to DNFB had the same properties.