Intra-ocular transplantation of heterologous tissues.
1950; National Institutes of Health; Volume: 10; Issue: 1 Linguagem: Inglês
Autores
Donald S. Morris, John R. McDonald, Frank C. Mann,
Tópico(s)Ocular Disorders and Treatments
ResumoSummary and Conclusions Transplants of 40 malignant tumors of human beings into the anterior chambers of 167 guinea pigs did not survive, with one exception. In this single exception partial survival of resistant squamous-epithelial elements occurred with a marked reaction of the host. Transplants of four malignant tumors and one specimen of normal tissue from human beings within the lens of the eyes of five guinea pigs survived, and in at least one case the transplant grew. The lenticular capsule prevented vascularization, infiltration, and destruction of the intralenticular transplants which were nourished by imbibition of nutrient material from the intra-ocular fluids through the capsule. Thus the avascular, intralenticular transplants are tantamount to in vivo tissue cultures. Intralenticular transplantation is probably of limited value in assessing the biologic characteristics of neoplasms, since these limited observations suggest that any heterologous tissue, benign or malignant, will survive within the lens.
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