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Excretion and catabolism of catecholamines in fish

1973; Elsevier BV; Volume: 4; Issue: 15 Linguagem: Inglês

10.1016/0010-4035(73)90001-3

1878-2388

Madeleine M. Mazeaud, F Mazeaud,

Pharmacological Effects and Assays

1. The urinary catabolites of labelled epinephrine and norepinerphrine were studied in a teleost, Salmo gairdneri, and in a selachian, Scyliorhinus canicula. 2. In both species, catecholamines undergo O-methylation, deamination, and conjugation. 3. In Salmo gairdneri DHMA, VMA, and MHPG are detected. Labelled epinephrine and norepinephrine result in labelled MN or NMN formation. MHPG represents about 50 per cent of the total amount of catecholamine catabolites. Unconjugated catabolites are in a minority. 4. In Salmo gairdneri labelled VMA, NMN, and MHPG are detected in the cephalic part of the kidney 1 hour after an injection of labelled norepinephrine. 5. In Scyliorhinus canicula labelled VMA, MHPG, and DHMA were detected after an injection of both catecholamines. As in Salmo gairdneri, labelled epinephrine and norepinephrine respectively result in labelled MN and NMN formation. VMA and O-methylated amines only (MN and NMN) are the main catabolites and are chiefly excreted in their conjugated forms. 6. The catabolism of catecholamines results in the formation of substances which are the same all along the scale of vertebrates.