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Mechanisms of Conjoint Failure of the Somatotrophic and Gonadal Axes in Ageing Men

2002; Wiley; Linguagem: Inglês

10.1002/0470846542.ch7

1935-4657

Johannes D. Veldhuis, Ali Iranmanesh, Thomas Mulligan, C. Y. Bowers,

Growth Hormone and Insulin-like Growth Factors

Mechanisms of Conjoint Failure of the Somatotrophic and Gonadal Axes in Ageing Men J. D. Veldhuis, J. D. Veldhuis Division of Endocrinology, University of Virginia School of Medicine, Charlottesville, Virginia 22908-0202, USASearch for more papers by this authorA. Iranmanesh, A. Iranmanesh Endocrine Section, Salem Veterans Affairs Medical Center, Salem, Virginia 24153, USASearch for more papers by this authorT. Mulligan, T. Mulligan Geriatrics and Extended Care Service, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USASearch for more papers by this authorC. Y. Bowers, C. Y. Bowers Department of Medicine SL53, Tulane University Medical Center, New Orleans, Louisiana 70112-2699, USASearch for more papers by this author J. D. Veldhuis, J. D. Veldhuis Division of Endocrinology, University of Virginia School of Medicine, Charlottesville, Virginia 22908-0202, USASearch for more papers by this authorA. Iranmanesh, A. Iranmanesh Endocrine Section, Salem Veterans Affairs Medical Center, Salem, Virginia 24153, USASearch for more papers by this authorT. Mulligan, T. Mulligan Geriatrics and Extended Care Service, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USASearch for more papers by this authorC. Y. Bowers, C. Y. Bowers Department of Medicine SL53, Tulane University Medical Center, New Orleans, Louisiana 70112-2699, USASearch for more papers by this author Book Editor(s):Derek J. Chadwick, Derek J. ChadwickSearch for more papers by this authorJamie A. Goode, Jamie A. GoodeSearch for more papers by this author First published: 09 January 2002 https://doi.org/10.1002/0470846542.ch7Citations: 5Book Series:Novartis Foundation Symposia Series Editor(s): Novartis Foundation, Novartis FoundationSearch for more papers by this author AboutPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShareShare a linkShare onFacebookTwitterLinked InRedditWechat Summary Endogenous growth hormone (GH) production falls by 50% every 7 years and bioavailable testosterone concentrations decline concomitantly by 12–15% every decade in ageing men. Despite this temporal parallelism, the neuroendocrine bases of the somatopause and gonadopause are not known. This knowledge deficit contrasts with the recent unfolding of new insights into the nature of oestrogen-dependent control of the GH–insulin-like growth factor (IGF)1 axis in pre- and postmenopausal women. The present overview examines the postulate that the pathophysiology of somatopause and gonadopause in ageing men is bidirectionally linked. According to this broader thesis, hyposomatotropism accentuates Leydig cell steroidogenic failure and, conversely, progressive androgen deficiency exacerbates the decline in GH–IGF1 output in ageing. Citing Literature Endocrine Facets of Ageing: Novartis Foundation Symposium 242, Volume 242 RelatedInformation