Clustering of Strength, Physical Function, Muscle, and Adiposity Characteristics and Risk of Disability in Older Adults
2011; Wiley; Volume: 59; Issue: 5 Linguagem: Inglês
10.1111/j.1532-5415.2011.03389.x
ISSN1532-5415
AutoresPeggy M. Cawthon, Kathleen M. Fox, Shravanthi R. Gandra, Matthew J. Delmonico, Chiun‐Fang Chiou, Mary S. Anthony, Paolo Caserotti, Stephen B. Kritchevsky, Anne B. Newman, Bret H. Goodpaster, Suzanne Satterfield, Steven R. Cummings, Tamara B. Harris,
Tópico(s)Health and Wellbeing Research
ResumoJournal of the American Geriatrics SocietyVolume 59, Issue 5 p. 781-787 Clustering of Strength, Physical Function, Muscle, and Adiposity Characteristics and Risk of Disability in Older Adults Peggy M. Cawthon PhD, MPH, Peggy M. Cawthon PhD, MPH From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorKathleen M. Fox MHS, PhD, Kathleen M. Fox MHS, PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorShravanthi R. Gandra PhD, Shravanthi R. Gandra PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorMatthew J. Delmonico PhD, MPH, Matthew J. Delmonico PhD, MPH From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorChiun-Fang Chiou PhD, Chiun-Fang Chiou PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorMary S. Anthony PhD, Mary S. Anthony PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorPaolo Caserotti PhD, Paolo Caserotti PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorStephen B. Kritchevsky PhD, Stephen B. Kritchevsky PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorAnne B. Newman MD, MPH, Anne B. Newman MD, MPH From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorBret H. Goodpaster PhD, Bret H. Goodpaster PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorSuzanne Satterfield MD, DrPH, Suzanne Satterfield MD, DrPH From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorSteven R. Cummings MD, Steven R. Cummings MD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorTamara B. Harris MD, MS, Tamara B. Harris MD, MS From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorfor the Health, Aging and Body Composition Study, for the Health, Aging and Body Composition Study From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this author Peggy M. Cawthon PhD, MPH, Peggy M. Cawthon PhD, MPH From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorKathleen M. Fox MHS, PhD, Kathleen M. Fox MHS, PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorShravanthi R. Gandra PhD, Shravanthi R. Gandra PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorMatthew J. Delmonico PhD, MPH, Matthew J. Delmonico PhD, MPH From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorChiun-Fang Chiou PhD, Chiun-Fang Chiou PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorMary S. Anthony PhD, Mary S. Anthony PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorPaolo Caserotti PhD, Paolo Caserotti PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorStephen B. Kritchevsky PhD, Stephen B. Kritchevsky PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorAnne B. Newman MD, MPH, Anne B. Newman MD, MPH From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorBret H. Goodpaster PhD, Bret H. Goodpaster PhD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorSuzanne Satterfield MD, DrPH, Suzanne Satterfield MD, DrPH From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorSteven R. Cummings MD, Steven R. Cummings MD From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorTamara B. Harris MD, MS, Tamara B. Harris MD, MS From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this authorfor the Health, Aging and Body Composition Study, for the Health, Aging and Body Composition Study From the *Research Institute, California Pacific Medical Center, San Francisco, California; †Strategic Healthcare Solutions, LLC, Monkton, Maryland; ‡Amgen, Thousand Oaks, California; §University of Rhode Island, Kingston, Rhode Island; ∥Intramural Research Program, National Institute on Aging, Bethesda, Maryland; #Sticht Center on Aging, School of Medicine, Wake Forest University, Winston-Salem, North Carolina; **University of Pittsburgh, Pittsburgh, Pennsylvania; and ††University of Tennessee, Memphis, Tennessee.Search for more papers by this author First published: 13 May 2011 https://doi.org/10.1111/j.1532-5415.2011.03389.xCitations: 58 Address correspondence to Peggy M. Cawthon, California Pacific Medical Center Research Institute, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, CA 94107. E-mail: pcawthon@sfcc-cpmc.net Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract OBJECTIVES: To empirically identify groupings of strength, physical performance, adiposity, and lean mass and test how such groupings of these interrelated measures may relate to disability risk. DESIGN: Prospective Health, Aging and Body Composition Study. SETTING: Two U.S. clinical centers. PARTICIPANTS: One thousand two hundred sixty-three women and 1,221 men. MEASUREMENTS: Weight, strength (knee extension, grip); walking speed, chair stands, dual X-ray absorptiometry (fat and lean mass for total body, arm, and leg; percent fat), and thigh computed tomography scans (muscle area, muscle density). Analyses were stratified according to sex. Factor analysis reduced these variables into a smaller number of components, and proportional hazards models assessed risk of major disability for the components identified. RESULTS: In both sexes, factor analysis reduced the 14 individual variables into three components that explained 76% to 77% of the data variance: Factor 1, an adiposity component, with strong loading by fat mass, weight, and muscle density; Factor 2, a strength and lean body size component with strong loading by lean mass, weight, and strength; Factor 3, a physical performance component with positive loading by walking speed and chair stand performance. Factor 1 (adiposity) and Factor 3 (performance) but not Factor 2 (strength and lean body size) were associated with disability over 6.1±2.6 years. CONCLUSION: The adiposity and physical performance constructs but not the strength and lean body size construct were associated with disability risk, suggesting that adiposity and performance should be considered as risk factors for disability. Citing Literature Volume59, Issue5May 2011Pages 781-787 RelatedInformation
Referência(s)