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CHA 2 DS 2 VASc Score as a Predictor of Cardiovascular Events in Ambulatory Patients without Atrial Fibrillation
2015; Wiley; Volume: 38; Issue: 12 Linguagem: Inglês
10.1111/pace.12744
ISSN1540-8159
AutoresGUSTAVO FREB POLENZ, Tiago Luiz Luz Leiria, Vidal Essebag, Marcelo Lapa Kruse, Leonardo Martins Pires, THAIZE BRISOLARA NOGUEIRA, Raphael Boesche Guimarães, Roberto T. Sant’Anna, Gustavo Glotz de Lima,
Tópico(s)Cardiac Imaging and Diagnostics
ResumoPacing and Clinical ElectrophysiologyVolume 38, Issue 12 p. 1412-1417 ELECTROPHYSIOLOGY CHA2DS2VASc Score as a Predictor of Cardiovascular Events in Ambulatory Patients without Atrial Fibrillation GUSTAVO FREB POLENZ M.D., GUSTAVO FREB POLENZ M.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorTIAGO LUIZ LUZ LEIRIA M.D., Ph.D., Corresponding Author TIAGO LUIZ LUZ LEIRIA M.D., Ph.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilAddress for reprints: Tiago Luiz Luz Leiria, M.D., Ph.D., Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Av. Princesa Isabel, 395, Santana, CEP 90620-000, Porto Alegre, RS, Brazil. Fax: +555132303687; e-mail: drleiria@gmail.comSearch for more papers by this authorVIDAL ESSEBAG M.D., Ph.D., VIDAL ESSEBAG M.D., Ph.D. Cardiac Electrophysiology, McGill University Health Centre, Montreal, Québec, CanadaSearch for more papers by this authorMARCELO LAPA KRUSE M.D., M.Sc., MARCELO LAPA KRUSE M.D., M.Sc. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorLEONARDO MARTINS PIRES M.D., M.Sc., LEONARDO MARTINS PIRES M.D., M.Sc. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorTHAIZE BRISOLARA NOGUEIRA M.D., THAIZE BRISOLARA NOGUEIRA M.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorRAPHAEL BOESCHE GUIMARÃES M.D., RAPHAEL BOESCHE GUIMARÃES M.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorROBERTO TOFANI SANTANNA M.D., ROBERTO TOFANI SANTANNA M.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorGUSTAVO GLOTZ DE LIMA M.D., Ph.D., GUSTAVO GLOTZ DE LIMA M.D., Ph.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this author GUSTAVO FREB POLENZ M.D., GUSTAVO FREB POLENZ M.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorTIAGO LUIZ LUZ LEIRIA M.D., Ph.D., Corresponding Author TIAGO LUIZ LUZ LEIRIA M.D., Ph.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilAddress for reprints: Tiago Luiz Luz Leiria, M.D., Ph.D., Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Av. Princesa Isabel, 395, Santana, CEP 90620-000, Porto Alegre, RS, Brazil. Fax: +555132303687; e-mail: drleiria@gmail.comSearch for more papers by this authorVIDAL ESSEBAG M.D., Ph.D., VIDAL ESSEBAG M.D., Ph.D. Cardiac Electrophysiology, McGill University Health Centre, Montreal, Québec, CanadaSearch for more papers by this authorMARCELO LAPA KRUSE M.D., M.Sc., MARCELO LAPA KRUSE M.D., M.Sc. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorLEONARDO MARTINS PIRES M.D., M.Sc., LEONARDO MARTINS PIRES M.D., M.Sc. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorTHAIZE BRISOLARA NOGUEIRA M.D., THAIZE BRISOLARA NOGUEIRA M.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorRAPHAEL BOESCHE GUIMARÃES M.D., RAPHAEL BOESCHE GUIMARÃES M.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorROBERTO TOFANI SANTANNA M.D., ROBERTO TOFANI SANTANNA M.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this authorGUSTAVO GLOTZ DE LIMA M.D., Ph.D., GUSTAVO GLOTZ DE LIMA M.D., Ph.D. Electrophysiology Department of the Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, Porto Alegre, Rio Grande do Sul, BrazilSearch for more papers by this author First published: 27 August 2015 https://doi.org/10.1111/pace.12744Citations: 13 Conflict of Interest: The authors declare no conflicts of interest relevant to this manuscript. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Background New evidence suggests that the CHA2DS2VASc (congestive heart failure, hypertension [HTN], age, diabetes, stroke, vascular disease, and female gender) score may be a reliable tool to predict the risk of thromboembolic events in patients without documented atrial fibrillation (AF). Methods We performed a prospective cohort study of outpatients without AF or flutter, who were not using oral anticoagulation. Clinical characteristics were assessed and patients were stratified according to the CHA2DS2VASc score. We evaluated the incidence of major adverse cardiac outcomes and its relation to the CHA2DS2VASc score during the follow-up. Results Four hundred sixty-eight patients without AF were enrolled with a mean follow-up of 12 ± 6 months. Age was 64.9 ± 11.3 years. The prevalence of HTN was 88.4%, diabetes 37.6%, heart failure 26.3%, and vascular disease 61.7%. Overall, CHA2DS2VASc score was 3.4 ± 1.4. There were 15 major adverse cardiac outcomes during 12.2 months of follow-up (overall incidence of 3.2 per 100 person-years). We found significant differences in relation to gender, age, previous stroke, and follow-up length in patients with and without adverse outcomes. The CHA2DS2VASc score was higher in those with adverse outcomes (4.2 ± 1.7 vs 3.4 ± 1.4; P = 0.035). Patients with a CHA2DS2VASc ≥6 had a relative risk for adverse outcomes of 4.2 (95% confidence interval: 1.27–13.90). Conclusions In our population, CHA2DS2VASc score predicts major adverse cardiac outcomes, including stroke and death, in a cohort of patients without AF. Citing Literature Volume38, Issue12December 2015Pages 1412-1417 RelatedInformation
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