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INHALATION OF PENICILLIN AEROSOL IN PATIENTS WITH BRONCHIAL ASTHMA, CHRONIC BRONCHITIS, BRONCHIECTASIS AND LUNG ABSCESS: PRELIMINARY REPORT

1945; American College of Physicians; Volume: 22; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-22-4-485

1539-3704

Alvan L. Barach, Frederick H. Silberstein, Enid T. Oppenheimer, Thomas H. Hunter, Max Soroka,

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Article1 April 1945INHALATION OF PENICILLIN AEROSOL IN PATIENTS WITH BRONCHIAL ASTHMA, CHRONIC BRONCHITIS, BRONCHIECTASIS AND LUNG ABSCESS: PRELIMINARY REPORTALVAN L. BARACH, M.D., F.A.C.P., FREDERICK H. SILBERSTEIN, M.D., ENID TRIBE OPPENHEIMER, B.S., THOMAS HUNTER, M.D., MAX SOROKA, B.S.ALVAN L. BARACH, M.D., F.A.C.P.Search for more papers by this author, FREDERICK H. SILBERSTEIN, M.D.Search for more papers by this author, ENID TRIBE OPPENHEIMER, B.S.Search for more papers by this author, THOMAS HUNTER, M.D.Search for more papers by this author, MAX SOROKA, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-4-485 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this communication is to present the results of an exploratory study on the technic, safety and clinical effectiveness of inhaling penicillin aerosol in patients with bronchopulmonary infection. Many questions concerning dosage of the drug, length of treatment and choice of apparatus require further investigation. Our preliminary findings are reported in order that other workers in this field may study this relatively simple method of local application of penicillin to the bronchi and lung parenchyma, since the response in some patients has been of an encouraging nature. That penicillin aerosol penetrates the lungs and may be recovered from...Bibliography1. BRYSONSANSOMELASKIN VES: Aerosolization of penicillin solutions, Science, 1944, c, 33-35. CrossrefGoogle Scholar2. HEUBNER W: Ueber inhalation zerstäubter Flüssigheiten, Ztschr. f. d. ges. exper. Med., Berl., 1919, x, 269-332, 2 pl. Google Scholar3. LAGEDER K: Untersuchungen ueber den Einfluss inhalierten Adrenalins auf die Lungenventilation beim Asthma bronchiale und euber dessen Allgemeinwirkung, Beitr. z. Klin. d. Tuberk., 1933, lxxxiii, 605-618. CrossrefGoogle Scholar4. GRAESERROWE JBAH: Inhalation of epinephrine for relief of asthmatic symptoms, Jr. Allergy, 1935, vi, 415-420. CrossrefGoogle Scholar5. 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CHAMBERSHARRISSCHUMANNFERGUSON LATNFLK: Use of microcrystals of sulfathiazole in surgery, Jr. Am. Med. Assoc., 1942, cxix, 324-327. CrossrefGoogle Scholar16. BARACHMOLOMUTSOROKA ALNM: Inhalation of nebulized promin in experimental tuberculosis, Am. Rev. Tuberc., 1942, xlvi, 268-276. Google Scholar17. EDLINBROBROWITZSAFFORDBUTLER JSIDFKFS: Promin inhalational therapy in pulmonary tuberculosis, Am. Rev. Tuberc., 1944, l, 543-555. Google Scholar18. STACEY JW: Inhalation of nebulized solutions of sulfonamides in treatment of bronchiectasis, Dis. Chest, 1943, ix, 303-306. Google Scholar19. DAWSONHOBBY MHGL: The clinical use of penicillin: observations in 100 cases, Jr. Am. Med. Assoc., 1944, cxxiv, 611-622. CrossrefGoogle Scholar20. LOCKEY SD: Inhalation of oxygen and 1:100 epinephrine hydrochloride plus 5 per cent glycerin for relief of asthmatic attacks, Jr. Allergy, 1943, xiv, 382-385. CrossrefGoogle Scholar21. ECKMANRUMSEYBARACH MCCAL: To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication November 24, 1944.From the Department of Medicine, Columbia University, College of Physicians and Surgeons, New York City, and the Research Service, First (Columbia) Division, Goldwater Memorial Hospital, Welfare Island, New York.The penicillin was provided by the Office of Scientific Research and Development from supplies assigned by the Committee on Medical Research for clinical investigations recommended by the Committee on Chemotherapeutics and Other Agents of the National Research Council.This research was aided by a grant from the Josiah Macy, Jr. Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliographyBacteriology of the Lower Respiratory Tract in Health and Chronic DiseasesThe Changing Picture of Lung Abscess TherapyAsthma bronchialeALLERGY, ANTIBIOTICS AND CHEMOTHERAPEUTICSXIX Studies with Steam Generated AerosolsAdministration of Cortisone by the Aerosol Method in the Treatment of Bronchial AsthmaACUTE SUPPURATIVE BRONCHITIS AND BRONCHIOLITIS IN CHRONIC PULMONARY DISEASE: DIAGNOSIS AND MANAGEMENT*LEONARD CARDON, M.D., F.A.C.P., LOUIS LEMBERG, M.D., REGINA S. GREENEBAUM, M.D.Treatment of Acute and Chronic Bronchitis with Penicillin and Sulfametin Aerosol1Industrial Hygiene SectionAerosol Therapy of Bronchopulmonary DiseasesTREATMENT OF A LUNG ABSCESS BY INHALATION OF MICROPULVERISED PENICILLINRELATIVE EFFECTIVENESS OF PARENTERAL, INTRATRACHEAL, AND AEROSOL PENICILLIN IN CHRONIC SUPPURATIVE DISEASE OF THE LUNGALLERGY TO MOULDS IN SWEDEN.Antibacterial ChemotherapyBibliographyUse of intermittent positive pressure breathing combined with nebulization in pulmonary diseaseFacts and Fancies in the Management of the Seriously Ill Patient with Bronchial AsthmaA Demand Valve for the Administration of Aerosols of Penicillin and StreptomycinMEDICAL TREATMENT OF ACUTE AND CHRONIC PULMONARY ABSCESSESAerosol therapyBronchiectasisBronchiectasis: Treatment and PreventionAerosol Therapy of Respiratory DiseasePenicillin aerosol therapy in bronchiectasis, lung abscess and chronic bronchitisPenicillin aerosol in the prevention and treatment of respiratory infections in allergic patientsInhalation Therapy in Chronic Bronchial InfectionsPostoperative pulmonary atelectasisStreptomycin Treatment of Pulmonary InfectionsPenicillin in intractable asthmaPhysiologic and Antibiotic (Penicillin) Therapy in Chronic Hypertrophic Pulmonary EmphysemaPenicillin Inhalation TherapyThe treatment of asthma by inhalation of aerosol of aminophyllinBronchiectasisChemotherapy : Penicillin, Sulfonamides, Streptomycin and TyrothricinPenicillin Aerosol: Contribution of the Chemical Warfare Service to MedicinePenicillin aerosol and negative pressure in the treatment of sinusitisPNEUMOTHORAX THERAPY FOR EARLY BRONCHIECTASISPENICILLIN INHALATION IN PULMONARY DISEASEINHALED PENICILLIN IN BRONCHIAL INFECTIONSMORTALITY TRENDS IN DEGENERATIVE DISEASECHEMOTHERAPEUTIC MISTSThe Nonsurgical Management of Bronchiectasispharmacy of Penicillin Used by InhalationPenicillin in Iodized Oil for Instillation Into the LungsMethod for experimental control of particle size of therapeutic aerosols 1 April 1945Volume 22, Issue 4Page: 485-509KeywordsChemotherapeutic agentsChronic bronchitisDrugsHospital medicineInhalationLungsPenicillinSafetySafety studiesSurgeons ePublished: 1 December 2008 Issue Published: 1 April 1945 PDF downloadLoading ...