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Thyroid nodular hyperplasia

1993; Elsevier BV; Volume: 69; Issue: 1 Linguagem: Inglês

10.1016/0165-4608(93)90108-x

1873-4456

Lúcia Roque, Paula Gomes, Cecília Correia, Paula Soares, Jorge Soares, Sérgio Castedo,

Head and Neck Anomalies

Cytogenetic study of 14 thyroid nodular hyperplasias revealed a hyperdiploid karyotype in two cases (14%) and a normal chromosomal complement in the remaining cases. Some of the numerical alterations found were identical to the ones considered characteristic of a subset of thyroid adenomas (+;5, +;7, +;9, +;12, +;14, and +;16). Our findings suggest that the cytogenetic events involved in the pathogenesis of thyroid hyperplastic lesions and benign tumors may be closely related, which supports the hypothesis of a biologic “continuum” between these two types of lesions.