Development and disability
2002; BMJ; Volume: 86; Issue: Supplement 1 Linguagem: Inglês
10.1136/adc.86.suppl_1.a30
ISSN1468-2044
Autores Tópico(s)Children's Physical and Motor Development
ResumoAims: To investigate the physical and neurodevelopmental wellbeing of ICSI conceived 5 year olds, compared with naturally conceived controls.Methods: Children were singleton, first born and caucasian.A paediatrician and a psychologist performed a comprehensive assessment of these children.The psychologist was blinded to conception type.A sociodemographic, medical and developmental history was ascertained whilst the child was assessed using WIPPSI-R, McCarthy, and Bene-Anthony family relations tests.After this, a physical examination was performed by the paediatrician including visual testing, pure tone audiometry, measurement of growth and ascertainment of congenital abnormalities.Results: For this interim analysis 138 study and 105 control children have been assessed.A range of sociodemograhic factors, including social class, parental level of education, maternal smoking and parental drinking were comparable between groups.Maternal age of study children, 34.2years, was significantly older than in the control group, 31.7years(p<0.0001).There was no sex bias although the study children, 5.08 years, were slightly older than control children, 4.96years (p<0.01) and the study children were born slightly less mature.Growth parameters were not statistically different at examination.Hospital admissions were similar and the occurrence of major childhood illnesses and surgery were no different.At this stage, combined major and minor congenital abnormality rates were also comparable (ICSI 38/138, control 19/105).WIPPSI-R, McCarthy and Bene-Anthony scores were comparable and around the mean for age.Conclusions: Despite continuing concerns about the safety of this invasive form of in-vitro fertilisation, our findings to date suggest ICSI conceived 5 year olds are similar to their matched naturally conceived controls.
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