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Glucose Transport in the Renal Proximal Tubule

1992; Wiley; Linguagem: Inglês

10.1002/cphy.cp080243

2040-4603

Mel Silverman, R. James Turner,

Neonatal Health and Biochemistry

The sections in this article are: 1 General Characteristics 1.1 Glucose Handling by the Whole Kidney 1.2 Tubular Site of Reabsorption 1.3 D-Glucose Handling by the Intact Proximal Tubule 2 Current Understanding of the Mechanism of Glucose Reabsorption 2.1 Components of the Reabsorptive Mechanism 2.2 Energetics: Gradient Hypothesis 2.3 Na+ Dependence of Luminal versus Basolateral D-glucose Transport 2.4 Kinetics and Stoichiometry 2.5 Systematics of D-Glucose Reabsorption at the Cellular and Tubular Levels 2.6 Specificity Characteristics 3 Abnormalities of Glucose Reabsorption in the Renal Tubule 3.1 Renal Glycosuria 3.2 Fanconi's Syndrome 3.3 Specific Defects of D-Glucose Transport 4 Molecular Characterization of the Components of the D-Glucose Reabsorptive Pathway Across the Renal Proximal Tubule 4.1 The Luminal Na+-Dependent D-Glucose Carrier 4.2 The Basolateral Na+-Independent D-Glucose Carrier 5 Molecular Mechanism of Operation of the Na+-Dependent D-Glucose Transporter 6 conclusion6 Conclusion