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Trisomy 12 in chronic lymphocytic leukemia

1994; Elsevier BV; Volume: 72; Issue: 2 Linguagem: Inglês

10.1016/0165-4608(94)90119-8

1873-4456

Yok‐Lam Kwong, Jenny Pang, L.M. Ching, H.W. Liu, Raymond Liang, L.C. Chan,

Genomic variations and chromosomal abnormalities

B-cell chronic lymphocytic leukemia (CLL) is a rare disorder in the Chinese population. We evaluated the use of fluorescence in situ hybridization (FISH) with a chromosome 12-specific probe in the detection of trisomy 12 in interphase cell of 19 Chinese CLL patients. FISH successfully detected trisomy 12 in two cases, one of which had normal conventional cytogenetic findings, giving an incidence of 10%. The low incidence of trisomy 12 in our CLL patients may also reflect a biologic difference of this rare disorder in our population, compared to that of the West.