Genomic structure and promoter analysis of putative mouse acetyl‐CoA transporter gene
2000; Wiley; Volume: 473; Issue: 2 Linguagem: Inglês
10.1016/s0014-5793(00)01524-6
ISSN1873-3468
AutoresRoop Singh Bora, Shinichi Ichikawa, Akiko Kanamori, Yoshio Hirabayashi,
Tópico(s)Ubiquitin and proteasome pathways
ResumoThe acetyl‐CoA transporter gene ( Acatn ) encodes a hydrophobic, multitransmembrane protein that is involved in the process of O ‐acetylation of sialic acid residues on gangliosides. O ‐Acetylated gangliosides have been found to play important roles in tissue development and organization during early embryonic stages. We have cloned the gene for mouse acetyl‐CoA transporter. The gene spans approximately 20 kb and is composed of seven exons and six introns. A single transcription initiation site, 371 bp upstream of the ATG start codon, was identified. The promoter region was found to lack a TATA box. However, several potential transcription factor binding motifs such as AP1, AP2, C/EBPα, C/EBPβ, HSF, GATA2 and MZF1 were identified in the promoter region.
Referência(s)