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Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.

1988; Springer Nature; Volume: 7; Issue: 7 Linguagem: Inglês

10.1002/j.1460-2075.1988.tb03042.x

1460-2075

Ann Richmond, E Balentien, Herbert Thomas, Gail Flaggs, David Barton, Joachim Spiess, Roberta Bordoni, Uta Francke, Rik Derynck,

Cytokine Signaling Pathways and Interactions

Research Article1 July 1988free access Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. A. Richmond A. Richmond VA Medical Center, Atlanta, GA. Search for more papers by this author E. Balentien E. Balentien VA Medical Center, Atlanta, GA. Search for more papers by this author H. G. Thomas H. G. Thomas VA Medical Center, Atlanta, GA. Search for more papers by this author G. Flaggs G. Flaggs VA Medical Center, Atlanta, GA. Search for more papers by this author D. E. Barton D. E. Barton VA Medical Center, Atlanta, GA. Search for more papers by this author J. Spiess J. Spiess VA Medical Center, Atlanta, GA. Search for more papers by this author R. Bordoni R. Bordoni VA Medical Center, Atlanta, GA. Search for more papers by this author U. Francke U. Francke VA Medical Center, Atlanta, GA. Search for more papers by this author R. Derynck R. Derynck VA Medical Center, Atlanta, GA. Search for more papers by this author A. Richmond A. Richmond VA Medical Center, Atlanta, GA. Search for more papers by this author E. Balentien E. Balentien VA Medical Center, Atlanta, GA. Search for more papers by this author H. G. Thomas H. G. Thomas VA Medical Center, Atlanta, GA. Search for more papers by this author G. Flaggs G. Flaggs VA Medical Center, Atlanta, GA. Search for more papers by this author D. E. Barton D. E. Barton VA Medical Center, Atlanta, GA. Search for more papers by this author J. Spiess J. Spiess VA Medical Center, Atlanta, GA. Search for more papers by this author R. Bordoni R. Bordoni VA Medical Center, Atlanta, GA. Search for more papers by this author U. Francke U. Francke VA Medical Center, Atlanta, GA. Search for more papers by this author R. Derynck R. Derynck VA Medical Center, Atlanta, GA. Search for more papers by this author Author Information A. Richmond1, E. Balentien1, H. G. Thomas1, G. Flaggs1, D. E. Barton1, J. Spiess1, R. Bordoni1, U. Francke1 and R. Derynck1 1VA Medical Center, Atlanta, GA. The EMBO Journal (1988)7:2025-2033https://doi.org/10.1002/j.1460-2075.1988.tb03042.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Melanoma growth stimulatory activity (MGSA) is a mitogenic polypeptide secreted by Hs294T human melanoma cells. Comparison of the N-terminal sequences of the 13 and 16 kd MGSA species with the cDNA sequence revealed that the mature form of human MGSA is maximally 73 amino acids long. Expression of the cDNA in mammalian cells results in the secretion of this peptide with mitogenic activity. MGSA is structurally related to the platelet-derived beta-thromboglobulin and to several other polypeptides. These factors may constitute a family of growth factors. MGSA mRNA was detected in a variety of cell types. The level of MGSA mRNA in melanoma cells is strongly elevated by treatment with MGSA. MGSA is the gene product of a recently detected gene gro. The gene was mapped to chromosome 4 (region q13––q21). This same region also contains genes for two of the structurally related factors, for c-kit, a receptor for an as yet unidentified ligand, and for 'piebald trait', an inherited skin pigmentation disorder. Previous ArticleNext Article Volume 7Issue 71 July 1988In this issue RelatedDetailsLoading ...