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Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+ lymphocytopenia

2011; Wiley; Volume: 87; Issue: 1 Linguagem: Inglês

10.1111/j.1600-0609.2011.01619.x

1600-0609

Carlos Cervera, Francesc Fernández‐Avilés, Oscar De La Calle-Martin, Xavier Bosch, Montserrat Rovira, Montse Plana, Asunción Moreno, Felipe García, José M. Miró, Antonio Martı́nez, Teresa Gallart, Enric Carreras, Joan Bladé, José M. Gatell,

T-cell and B-cell Immunology

A 40-year-old man with severe chronic idiopathic CD4+ lymphocytopenia complicated with opportunistic infections was successfully treated with non-myeloablative allogeneic hematopoietic stem cell transplantation. After conditioning with fludarabine plus low dose of total-body irradiation, CD34+ peripheral blood stem cells obtained by leukapheresis from his HLA-identical sister were infused. T cell and myeloid complete chimerism was achieved at day +28 and remained stable during the follow-up period. The patient did not develop infectious complications during the procedure. At 35 months of follow-up, his CD4+ T cell count was 1019 cells per microliter. Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia.