FTY720-Induced Conversion of Conventional Foxp3−CD4+ T Cells to Foxp3+ Regulatory T Cells in NOD Mice
2011; Wiley; Volume: 66; Issue: 5 Linguagem: Inglês
10.1111/j.1600-0897.2011.01010.x
ISSN1600-0897
AutoresYun Sun, Wenjing Wang, Bin Shan, Jingfang Di, Linlin Chen, Lingling Ren, Weiping Li, Da‐Jin Li, Yi Lin,
Tópico(s)Sphingolipid Metabolism and Signaling
ResumoAmerican Journal of Reproductive ImmunologyVolume 66, Issue 5 p. 349-362 ORIGINAL ARTICLE FTY720-Induced Conversion of Conventional Foxp3−CD4+ T Cells to Foxp3+ Regulatory T Cells in NOD Mice Yun Sun, Yun Sun Department of Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China These authors contributed equally.Search for more papers by this authorWenjing Wang, Wenjing Wang Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China These authors contributed equally.Search for more papers by this authorBin Shan, Bin Shan Department of Medicine, Tulane University Healthy Sciences Center, New Orleans, LA, USA These authors contributed equally.Search for more papers by this authorJingfang Di, Jingfang Di Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaSearch for more papers by this authorLinlin Chen, Linlin Chen Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaSearch for more papers by this authorLingling Ren, Lingling Ren Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaSearch for more papers by this authorWeiping Li, Weiping Li Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaSearch for more papers by this authorDa-Jin Li, Da-Jin Li Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, ChinaSearch for more papers by this authorYi Lin, Yi Lin Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaSearch for more papers by this author Yun Sun, Yun Sun Department of Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China These authors contributed equally.Search for more papers by this authorWenjing Wang, Wenjing Wang Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China These authors contributed equally.Search for more papers by this authorBin Shan, Bin Shan Department of Medicine, Tulane University Healthy Sciences Center, New Orleans, LA, USA These authors contributed equally.Search for more papers by this authorJingfang Di, Jingfang Di Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaSearch for more papers by this authorLinlin Chen, Linlin Chen Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaSearch for more papers by this authorLingling Ren, Lingling Ren Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, ChinaSearch for more papers by this authorWeiping Li, Weiping Li Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaSearch for more papers by this authorDa-Jin Li, Da-Jin Li Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, ChinaSearch for more papers by this authorYi Lin, Yi Lin Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaSearch for more papers by this author First published: 27 May 2011 https://doi.org/10.1111/j.1600-0897.2011.01010.xCitations: 19 Yi Lin, Institute of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China. E-mail: [email protected]; or Da-Jin Li, Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200011, China. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Citation Sun Y, Wang W, Shan B, Di J, Chen L, Ren L, Li W, Li D-J, Lin Y. FTY720-induced conversion of conventional Foxp3−CD4+ T cells to Foxp3+ regulatory T cells in NOD mice. Am J Reprod Immunol 2011; 66: 349–362 Problem FTY720 is known as an agonist of sphingosine-1-phosphate (S1P) receptor, but little is known about the possibility that FTY720 induces the conversion of conventional Foxp3−CD4+ T cells to Foxp3+ regulatory T cells in non-obese diabetic (NOD) mice. Method of study FTY720 treatment was performed using Foxp3−CD4+ T cells purified from NOD mice. Results FTY720 caused an increase in Foxp3+ Treg cells in lymphoid organs in NOD mice. FTY720 effectively induced Foxp3 expression in Foxp3−CD4+ T cells both in vitro and in vivo, an effect that was inhibited by a TGF-β-neutralizing antibody or the proinflammatory cytokine IL-6. T-cell-mediated embryo rejection in NOD mice was prevented upon FTY720 treatment. Conclusions The use of FTY720 along with Ag administration may represent a useful therapeutic strategy to selectively expand Ag-specific Foxp3+ Tregs to intervene autoimmune and infectious diseases. 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