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Lack of Feminization of the Cremaster Nucleus in Cryptorchid Androgen Insensitive Rats

1994; Lippincott Williams & Wilkins; Volume: 152; Issue: 6 Part 2 Linguagem: Inglês

10.1016/s0022-5347(17)31658-0

1527-3792

Julia Spencer Barthold, Hank R. Mahler, Bruce W. Newton,

Hypothalamic control of reproductive hormones

No AccessJournal of Urology1 Dec 1994Lack of Feminization of the Cremaster Nucleus in Cryptorchid Androgen Insensitive Rats Julia Spencer Barthold, Hank R. Mahler, and Bruce W. Newton Julia Spencer BartholdJulia Spencer Barthold More articles by this author , Hank R. MahlerHank R. Mahler More articles by this author , and Bruce W. NewtonBruce W. Newton More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)31658-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Androgens may control rat testicular descent via effects on the genitofemoral nerve or cranial gonadal ligaments. Androgen-mediated release of calcitonin gene-related peptide from the genitofemoral nerve (whose motoneuron cell bodies reside in the sexually dimorphic cremaster nucleus) may stimulate cremaster sac formation and testicular descent. Alternatively, androgens may cause regression of cranial gonadal ligaments and thereby allow the testes to descend. To evaluate these theories testicular position, and the cremaster sac and nucleus were studied in Tfm (androgen insensitive) rats. Testes were abdominal, inguinal and scrotal in 20%, 67% and 13% of Tfm male rats, respectively, and cranial ligaments were present in all cases. Mean cremaster nucleus motoneuron number was lower in female rats (70 ± 14) but not significantly different between normal male (256 ± 44) and Tfm male (231 ± 42) rats, and it correlated poorly with testicular position. Calcitonin gene-related peptide immunoreactivity was rarely observed in cremaster motoneurons. These data suggest that the cremaster nucleus is not androgen-dependent, calcitonin gene-related peptide release from cremaster motoneurons is not the likely mechanism of testicular descent and persistent cranial ligaments may cause cryptorchidism in the Tfm rat. © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByBARTHOLD J, KUMASI-RIVERS K, UPADHYAY J, SHEKARRIZ B and IMPERATO-MCGINLEY J (2018) TESTICULAR POSITION IN THE ANDROGEN INSENSITIVITY SYNDROME: IMPLICATIONS FOR THE ROLE OF ANDROGENS IN TESTICULAR DESCENTJournal of Urology, VOL. 164, NO. 2, (497-501), Online publication date: 1-Aug-2000.Barthold J, Mahler H, Sziszak T and Newton B (2018) Lack of Feminization of the Cremaster Nucleus by Prenatal Flutamide Administration in the Rat and PigJournal of Urology, VOL. 156, NO. 2S, (767-771), Online publication date: 1-Aug-1996. Volume 152Issue 6 Part 2December 1994Page: 2280-2286 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.Keywordscryptorchismandrogensmotor neuronsratsMetricsAuthor Information Julia Spencer Barthold More articles by this author Hank R. Mahler More articles by this author Bruce W. Newton More articles by this author Expand All Advertisement PDF DownloadLoading ...