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Identifying Protein Domains with the Pfam Database

2008; Wiley; Volume: 23; Issue: 1 Linguagem: Inglês

10.1002/0471250953.bi0205s23

1934-340X

Penny Coggill, ROBERT FINN, Alex Bateman,

Advanced Proteomics Techniques and Applications

Pfam is a database of protein domain families, with each family represented by multiple sequence alignments and profile hidden Markov models (HMMs). In addition, each family has associated annotation, literature references, and links to other databases. The entries in Pfam are available via the World Wide Web and in flatfile format. This unit contains detailed information on how to access and utilize the information present in the Pfam database, namely the families, multiple alignments, and annotation. Details on running Pfam, both remotely and locally are presented.