Steroidal analogues of unnatural configuration—VII
1973; Elsevier BV; Volume: 29; Issue: 8 Linguagem: Inglês
10.1016/0040-4020(73)80068-7
ISSN1464-5416
AutoresJames R. Bull, Albert A. Tuinman,
Tópico(s)Hormonal Regulation and Hypertension
ResumoConjugate methylation of 17β-hydroxy-des-a-oestr-9-en-5-one (1) and the derived 4,5-seco-steroid (6b) afforded the respective 9β-methyl compounds. Base-catalysed alkylation of 17β-hydroxy-9-methyl-des-a-9/gb-oestran-5-one (3a) resulted in attack at C(6); this result was used to prepare the anthrasteroid (5). Ring closure of the 9β-methyl-4,5-seco-steroid (8) derived from 6b afforded 17β-hydroxy-9-methyl-9β,10α-oestr-4-en-3-one (9a). Conjugate methylation of 17β-hydroxyoestra-4,9-dien-3-one (11) resulted in 1,4-addition to the dienone system.
Referência(s)