Herbal Products and GABA Receptors
2009; Elsevier BV; Linguagem: Inglês
10.1016/b978-008045046-9.00868-8
AutoresGraham A.R. Johnston, Mary Chebib, Rujee K. Duke, Sebastián P. Fernández, Jane R. Hanrahan, Tina Hinton, Kenneth N. Mewett,
Tópico(s)GABA and Rice Research
ResumoMany herbal products used to treat anxiety, cognitive disorders, and insomnia contain chemicals that influence the function of ionotropic receptors for the brain’s major inhibitory neurotransmitter γ-aminobutyric acid (GABA). These chemicals act in specific ways on such receptors. Their structural diversity and modes of action provide valuable leads for the development of new therapeutic agents and investigational tools. An understanding of the nature and function of these chemicals may offer a new approach to the quality control of herbal products. Investigations of their mechanisms of action have provided new insight into how ionotropic GABA receptors can be modulated by combinations of modulators.
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