Regulation of gastric acid secretion by gastrin in duodenal ulcer patients and healthy subjects
1992; Elsevier BV; Volume: 102; Issue: 4 Linguagem: Inglês
10.1016/0016-5085(92)90750-s
ISSN1528-0012
AutoresViktor E. Eysselein, Thomas O. Kovacs, Jan H. Kleibeuker, V. Maxwell, Terry J. Reedy, John H. Walsh,
Tópico(s)Gastrointestinal motility and disorders
ResumoTo examine the role of gastrin as a major mediator of meal-stimulated acid secretion at low and high intragastric pH, gastric acid secretory responses after exogenous and endogenous stimulation were studied in relation to circulating plasma gastrin levels in 19 healthy control subjects and in 18 patients with inactive duodenal ulcer disease.Gastrin was given intravenously in stepwise fourfold-increasing doses from 3.1 to 800 pmolkg-' -h-' over con-
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