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Age-Related Cognitive Decline in Hypercholesterolemic LDL Receptor Knockout Mice (LDLr−/−): Evidence of Antioxidant Imbalance and Increased Acetylcholinesterase Activity in the Prefrontal Cortex

2012; IOS Press; Volume: 32; Issue: 2 Linguagem: Inglês

10.3233/jad-2012-120541

1875-8908

Eduardo Luiz Gasnhar Moreira, Jade de Oliveira, Jean Costa Nunes, Danúbia Bonfanti Santos, Fernanda Costa Nunes, Daniella Serafim Couto Vieira, Rosa Maria Ribeiro‐do‐Valle, Fabrício A. Pamplona, Andreza Fabro de, Marcelo Farina, Roger Walz, Rui Daniel Prediger,

Neuroinflammation and Neurodegeneration Mechanisms

There is increasing evidence that hypercholesterolemia during midlife may represent a predictor of subsequent mild cognitive impairments and dementia decades later. However, the exact mechanism underlying this phenomenon remains unknown since plasmat