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Propafenone kinetics in the horse

1990; Elsevier BV; Volume: 23; Issue: 2 Linguagem: Inglês

10.1016/0160-5402(90)90035-j

1875-0206

Anna Puigdemont, J. Riu, Raimón Guitart, M. Arboix,

Pharmacological Effects and Assays

The propafenone kinetics after intravenous (i.v.) administration have been studied in the horse by a comparative analysis of compartmental and noncompartmental models. The pharmacokinetic parameters showed a large distribution (Vdss = 1021 ± 211 L) and a high clearance (Cl = 7019 ± 1746 mL/min) of the drug. The plasma concentrations were very low, under 1 μg/mL, in most cases; after 30 min these concentrations can be considered as nonefficient for the treatment of arrhythmia. There were no significant differences between pharmacokinetic parameters found with the use of compartmental and noncompartmental models.