Application of high-performance liquid chromatography to abnormal hemoglobin studies
1981; Elsevier BV; Volume: 670; Issue: 2 Linguagem: Inglês
10.1016/0005-2795(81)90010-6
ISSN1878-1454
AutoresJean‐Paul Boissel, Henri Wajcman, H. Fabritius, R Cabannes, Dominique Labie,
Tópico(s)Drug Transport and Resistance Mechanisms
ResumoA strategy is reported which allows the rapid characterization of different hemoglobins D found in Ivory Coast. It involves reverse-phase HPLC for peptide separations and micro-sequencing by the manual solid-phase method of Chang. Identification of hemoglobin Avicenna, hemoglobin Korle Bu and hemoglobin Cocody, a new variant (β 21 (B3) Asp → Asn), is described.
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