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THE CLINICAL USE OF SULPHANILAMIDE AND ITS DERIVATIVES IN THE TREATMENT OF INFECTIOUS DISEASES

1937; American College of Physicians; Volume: 11; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-11-4-575

1539-3704

Perrin H. Long, Eleanor A. Bliss,

HIV/AIDS drug development and treatment

Article1 October 1937THE CLINICAL USE OF SULPHANILAMIDE AND ITS DERIVATIVES IN THE TREATMENT OF INFECTIOUS DISEASESPERRIN H. LONG, M.D., ELEANOR A. BLISS, Sc.D.PERRIN H. LONG, M.D.Search for more papers by this author, ELEANOR A. BLISS, Sc.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-4-575 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe experimental observations 1, 2, 3, 4, 5, 6, 7 which have led to the use of sulphanilamide or its derivatives (chart 1) in the treatment of certain infectious diseases show that these chemicals have powerful chemotherapeutic effects in experimental infections. Clinical observations of their effects in human beings tend to confirm the laboratory results. In this communication we propose to discuss primarily the clinical application of these chemotherapeutic agents, and to detail the methods of their administration and the possible toxic effects which may become manifest in patients treated with sulphanilamide or its derivatives.It is interesting to...Bibliography1. DOMAGK G: Ein Beitrag zur Chemotherapie der bakteriellen Infektionen, Deutsch. med. Wchnschr., 1935, lxi, 250. CrossrefGoogle Scholar2. TREFOUELTREFOUELNITTIBOVET JJFD: Activite du p-aminophenylsulfamide sur les infections streptococciques experimentales de la souris et du lapin, Compt. rend. Soc. de biol., 1935, cxx, 756. Google Scholar3. COLEBROOKKENNY LM: Treatment of human puerperal infections in mice with prontosil, Lancet, 1936, i, 1279-1286. CrossrefGoogle Scholar4. BUTTLEGRAYSTEPHENSON GAWHD: Protection of mice against streptococcal and other infections by p-aminobenzenesulphonamide and related substances, Lancet, 1936, i, 1286. CrossrefGoogle Scholar5. 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