Cholelithiasis, Cholecystectomy, and Cancer; A Case-Control Study in Sweden
1982; Elsevier BV; Volume: 83; Issue: 3 Linguagem: Inglês
10.1016/s0016-5085(82)80205-9
ISSN1528-0012
AutoresAlbert B. Lowenfels, L Domellöf, C. Lindström, Frank Bergman, Mary Monk, Nils H. Sternby,
Tópico(s)Amoebic Infections and Treatments
ResumoTo study the relationship between gallstone disease (cholelithiasis and cholecystectomy) and cancer, a case-control study was performed in two Swedish hospitals comparing the prevalence of gallstone disease discovered at necropsy in 1422 subjects who died of cancer and 1205 subjects who did not die of cancer.Gallstone disease was more prevalent in the group of 131 women <50 yr of age who died of various cancers: odds ratio = 2.2, P < 0.01.When the analysis was restricted to 89 younger women who died of cancers that have been suggested to be related to diet (breast, reproductive system, gastrointestinal), the results became more significant: odds ratio = 3.3, P < 0.001.No such relationship was detected in older women or in men of any age.It seems likely that gallstone disease and several common cancers in younger Swedish women share similar epidemiologic and perhaps metabolic features .Gallstones share similar epidemiologic features with large bowel, breast, and female reproductive cancers, and it seems reasonable that these common diseases may be related through diet.However, it has been difficult to establish this association within individual population groups, perhaps because of selection of inappropriate controls, or because the groups studied were too small to detect important subgroup differences.
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