Produção Nacional
Revisado por pares
BCG (Bacille of Calmette?Gu�rin) revaccination leads to improved in vitro IFN-$gamma; response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children
2003; Elsevier BV; Volume: 21; Issue: 17-18 Linguagem: Inglês
10.1016/s0264-410x(02)00721-1
ISSN1873-2518
AutoresTheolis Barbosa, Sérgio Arruda, B Fernandes, Lucas P. Carvalho, Sílvia Cardoso, Sérgio Souza da Cunha, Maurício L. Barreto, Susan Martins Pereira, Laura C. Rodrigues, Manoel Barral‐Netto,
Tópico(s)Pneumocystis jirovecii pneumonia detection and treatment
ResumoTuberculin skin test (TST) response and cytokine production in finger stab-derived whole blood cultures from 136 BCG scar-positive school-age children were evaluated before and after BCG revaccination. Fifty-four percent of the children increased in vitro production of IFN-γ after revaccination, and this increase was highly significant for previously unresponsive children (P<0.0001). No correlation was found between TST response and cytokine production. Our data suggest that the in vitro IFN-γ response to mycobacterial antigens can be boosted by BCG revaccination and may contribute to the search of correlates of protection to be used for the evaluation of new mycobacterial vaccines.
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