A structural basis for the inhibition of collagen‐stimulated platelet function by quercetin and structurally related flavonoids
2010; Wiley; Volume: 159; Issue: 6 Linguagem: Inglês
10.1111/j.1476-5381.2009.00632.x
ISSN1476-5381
AutoresBernice Wright, Leonardo A. Moraes, C. Fred Kemp, William Mullen, Alan Crozier, Julie A. Lovegrove, Jonathan M. Gibbins,
Tópico(s)Hops Chemistry and Applications
ResumoMolecular mechanisms underlying the links between dietary intake of flavonoids and reduced cardiovascular disease risk are only partially understood. Key events in the pathogenesis of cardiovascular disease, particularly thrombosis, are inhibited by these polyphenolic compounds via mechanisms such as inhibition of platelet activation and associated signal transduction, attenuation of generation of reactive oxygen species, enhancement of nitric oxide production and binding to thromboxane A(2) receptors. In vivo, effects of flavonoids are mediated by their metabolites, but the effects and modes of action of these compounds are not well-characterized. A good understanding of flavonoid structure-activity relationships with regard to platelet function is also lacking.
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