Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa.
1996; National Institutes of Health; Volume: 56; Issue: 6 Linguagem: Inglês
Autores
Seung‐Chul Baik, Hee‐Shang Youn, Myung Hee Chung, WK Lee, Myung‐Je Cho, Gyung Hyuck Ko, Choong Kee Park, Hiroshi Kasai, Kwang‐Ho Rhee,
Tópico(s)Eosinophilic Esophagitis
ResumoHelicobacter pylori causes type B gastritis. It shows strong association with the development of gastric carcinoma. A plausible hypothesis for the missing link between H. pylori infection and gastric carcinogenesis involves oxygen free radical-induced DNA damage. To test this hypothesis, we compared the amount of 9-hydroxydeoxyguanosine, a marker for oxygen free radical-induced DNA damage, in the DNA of human gastric mucosa with and without H. pylori infection. Gastric antral biopsies were taken from pediatric patients and volunteers to select H. pylori-positive and H. pylori-negative specimens. The 8-hydroxydeoxyguanosine content of the gastric mucosal DNA was measured after H. pylori-positive and H. pylori-negative volunteers were identified. The increased level of oxidative DNA damage suggests the mechanistic link between H. pylori infection and gastric carcinoma.
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