Maximum Likelihood Estimation in Quantal Response Bioassay
1987; Oxford University Press; Linguagem: Inglês
10.1007/978-94-009-4794-8_13
ISSN1468-4357
Autores Tópico(s)Pesticide Residue Analysis and Safety
ResumoApproximate confidence intervals for the LD50 and LD90 doses and for the relative potency of one drug with respect to another in Bioassay are usually obtained using the Fieller method. A procedure is presented in this paper based on transformations of the parameters of interest, designed to facilitate normal, t, or log F approximations to the observed maximized or profile likelihood function. Comparisons with the Fieller method and applications to specific data sets are discussed. The procedure proposed illustrates methods and principles of statistical estimation that have a wide applicability.
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