Artigo Acesso aberto Revisado por pares

The effect of sildenafil citrate (Viagra) on cerebral blood flow in patients with cerebrovascular risk factors

2009; Wiley; Volume: 121; Issue: 6 Linguagem: Inglês

10.1111/j.1600-0404.2009.01307.x

ISSN

1600-0404

Autores

Mordechai Lorberboym, Ismaël Mena, Julio Wainstein, Mona Boaz, Yair Lampl,

Tópico(s)

Neurological Complications and Syndromes

Resumo

Acta Neurologica ScandinavicaVolume 121, Issue 6 p. 370-376 The effect of sildenafil citrate (Viagra) on cerebral blood flow in patients with cerebrovascular risk factors M. Lorberboym, M. Lorberboym Department of Nuclear Medicine, Edith Wolfson Medical Center, Holon, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorI. Mena, I. Mena Department of Nuclear Medicine, Clinica Las Condes and Universidad de Chile, Santiago, ChileSearch for more papers by this authorJ. Wainstein, J. Wainstein Diabetes unit, Edith Wolfson Medical Center, Holon, IsraelSearch for more papers by this authorM. Boaz, M. Boaz Epidemiology and Research Unit, Edith Wolfson Medical Center, Holon, IsraelSearch for more papers by this authorY. Lampl, Y. Lampl Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Neurology, Edith Wolfson Medical Center, Holon, IsraelSearch for more papers by this author M. Lorberboym, M. Lorberboym Department of Nuclear Medicine, Edith Wolfson Medical Center, Holon, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelSearch for more papers by this authorI. Mena, I. Mena Department of Nuclear Medicine, Clinica Las Condes and Universidad de Chile, Santiago, ChileSearch for more papers by this authorJ. Wainstein, J. Wainstein Diabetes unit, Edith Wolfson Medical Center, Holon, IsraelSearch for more papers by this authorM. Boaz, M. Boaz Epidemiology and Research Unit, Edith Wolfson Medical Center, Holon, IsraelSearch for more papers by this authorY. Lampl, Y. Lampl Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Neurology, Edith Wolfson Medical Center, Holon, IsraelSearch for more papers by this author First published: 17 May 2010 https://doi.org/10.1111/j.1600-0404.2009.01307.xCitations: 17 Mordechai Lorberboym, Department of Nuclear Medicine, Edith Wolfson Medical Center, Holon 58100, Israel.Tel.: +11 972 544 630930Fax: +11 972 3 5358494e-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Lorberboym M, Mena I, Wainstein J, Boaz M, Lampl Y. The effect of sildenafil citrate (Viagra) on cerebral blood flow in patients with cerebrovascular risk factors.Acta Neurol Scand: 2010: 121: 370–376.© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objectives – Sildenafil citrate is widely used for erectile dysfunction. The present study examined the short-term effects of sildenafil administration in individuals with cerebrovascular risk factors, including patients with a history of stroke. Materials and Methods – Twenty-five consecutive male patients with erectile dysfunction and vascular risk factors were included in the study. A perfusion brain SPECT study was performed at baseline and 1 h after the oral administration of sildenafil. Results – Associations between any of the risk factors and the perfusion scores were not detected, with the exception of stroke. Stroke patients showed significantly more areas with diminished perfusion after sildenafil administration compared to baseline. 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