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BIBTEX RIS

Antileishmanial activity of 3-(3,4,5-trimethoxyphenyl) propanoic acid purified from Amazonian Piper tuberculatum Jacq., Piperaceae, fruits

2010; Springer Science+Business Media; Volume: 20; Issue: 6 Linguagem: Inglês

10.1590/s0102-695x2010005000033

ISSN

1981-528X

Autores

Maria Goretty P. R. Ferreira, Anderson M. Kayano, Izaltina Silva-Jardim, Tatiany O. da Silva, Juliana P. Zuliani, Valdir Alves Facundo, Leonardo A. Calderón, Alexandre de Almeida-e-Silva, Pietro Ciancaglini, Rodrigo G. Stábeli,

Tópico(s)

Insect Pest Control Strategies

Resumo

Leishmanicidal activity of the 3-(3,4,5-trimethoxyphenyl) propanoic acid (TMPP) isolated from EtOH extracts of the Amazonian Piper turbeculatum Jacq. fruits was evaluated in vitro using Leishmania amazonensis promastigotes. The TMPP was assayed at concentrations of 1600 to 6.25 µg/mL for 24, 48, 72 and 96 h. Promastigotes viability was analyzed and the IC50 of TMPP was 145 µg/mL.

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